Clinical Trials

Information on ongoing or completed clinical trials can be found at the NCI Clinical Trials website.
For additional information regarding PrECOG clinical trials please contact PrECOG.

Collaboration with PrECOG

PrECOG collaborates with research groups and industry partners to explore innovative collaborations to achieve combined research interests. These research relationships offer different levels of partnership and are designed to facilitate research results. In these models, we align support of the study to achieve mutual developmental needs [e.g. data contributing to a potential regulatory filing or data request, publication, etc.]. To inquire further about research collaborations, please contact PrECOG.

Study IDTumorStudy StatusStudy TitleNCT ID
PrE0102BreastCompletedRandomized, Double-Blind, Placebo-Controlled Phase II Trial of Fulvestrant (Faslodex) Plus Everolimus in Post-Menopausal Patients With Hormone-Receptor Positive Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy https://clinicaltrials.gov/ct2/show/NCT01797120 NCT01797120
PrE0105 BreastCompletedA Phase 2 Study of Standard Chemotherapy Plus BSI-201 (a PARP Inhibitor) in the Neoadjuvant Treatment of Triple Negative Breast Cancer https://clinicaltrials.gov/ct2/show/NCT00813956 NCT00813956
PrE0109 AFT-05BreastRecruitingAFT-05: PALbociclib CoLlaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Early Breast Cancer https://clinicaltrials.gov/ct2/show/NCT02513394 NCT02513394
PrE0111 AFT-38BreastRecruitingAFT-38: A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy After Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast Cancer https://clinicaltrials.gov/ct2/show/NCT02947685 NCT02947685
PrE0204GICompletedA Multi-institutional, Single arm, Two-stage Phase II Trial of Nab-paclitaxel and Gemcitabine for First-line Treatment of Patients with Advanced or Metastatic Cholangiocarcinoma https://clinicaltrials.gov/ct2/show/NCT02181634 NCT02181634
PrE0401LymphomaCompletedPhase II Randomized Trial Comparing GA101 (Obinutuzumab) and Rituximab in Patients With Previously Untreated Low Tumor Burden Indolent Non-Hodgkin's Lymphoma https://clinicaltrials.gov/ct2/show/NCT01889797 NCT01889797
PrE0403LymphomaRecruitingPhase II Study of Venetoclax (ABT-199/GDC-0199) in Combination With Obinutuzumab and Bendamustine in Patients With High Tumor Burden Follicular Lymphoma as Front Line Therapy https://clinicaltrials.gov/ct2/show/NCT03113422 NCT03113422
PrE0404LymphomaRecruitingA Phase I/II Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma https://clinicaltrials.gov/ct2/show/NCT03323151 NCT03323151
PrE0501ThoracicCompletedA Randomized Phase II Study Evaluating Vandetanib (ZD6474) in Combination With Docetaxel and Carboplatin Followed by Placebo or Maintenance Therapy With Vandetanib in Patients With IIIb, IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) https://clinicaltrials.gov/ct2/show/NCT00687297 NCT00687297
PrE0502ThoracicCompletedAn Open-Label, Randomized, Phase IIIb Trial Evaluating The Efficacy And Safety Of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression Of Disease In Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) After First-Line Treatment With Bevacizumab Plus A Platinum Doublet-Containing Chemotherapy (MO22097) https://clinicaltrials.gov/ct2/show/NCT01351415 NCT01351415
PrE0504ThoracicActive, Not RecruitingA Phase I/II Study of Glembatumumab Vedotin in Patients With gpNMB-Expressing, Advanced or Metastatic Squamous Cell Carcinoma of the Lung https://clinicaltrials.gov/ct2/show/NCT02713828 NCT02713828
PrE0505ThoracicActive, Not RecruitingAnti - Programmed Death – Ligand 1 Antibody, Durvalumab, in Combination with Chemotherapy for the First-Line Treatment of Unresectable Mesothelioma https://clinicaltrials.gov/ct2/show/NCT02899195 NCT02899195
PrE0801GUCompletedNEXT: Subsequent exposure to tyrosine kinase inhibition (TKI) at recurrence after adjuvant therapy in renal cell carcinoma (RCC) https://clinicaltrials.gov/ct2/show/NCT01649180 NCT01649180
PrE0901LeukemiaCompletedPhase I Dose Finding/Phase II Placebo-Controlled Trial of Eltrombopag During Consolidation Therapy in Adults With Acute Myeloid Leukemia (AML) in Complete Remission https://clinicaltrials.gov/ct2/show/NCT01656252 NCT01656252
PrE1003Multiple MyelomaCompletedA Phase I/II Study of the Tolerability of Lenalidomide and Low Dose Dexamethasone in Previously Treated Multiple Myeloma Patients With Impaired Renal Function https://clinicaltrials.gov/ct2/show/NCT00790842 NCT00790842

Submit a Study Idea

Ideas for trials can be submitted to PrECOG for consideration by ECOG-ACRIN Cancer Research Group members in good standing, or other collaborators after discussions with PrECOG. Research ideas are developed and submitted to PrECOG by investigators as detailed study concepts. Once reviewed and approved, PrECOG will work to operationalize study concepts. The process for reviews is streamlined by parallel scientific [PrECOG/ECOG-ACRIN Cancer Research Group] and industry partner reviews. NCI review and approval is not required. Please contact PrECOG, to discuss any trial ideas.

Participate in PrECOG Trials

Sites are selected to participate in PrECOG trials based on current research standing, prior study performance, experience, and study feasibility. Potential sites provide information for specific study requirements under confidentiality including projected enrollment, research facility information, etc. Site selection follows all applicable regulations required by sponsors and researchers. Sites are notified of selection to participate after this process is complete. To ask about your site participating in PrECOG trials, please contact PrECOG.